Contraceptive Use and the Risk of Ectopic Pregnancy: A Multi-Center Case-Control Study

Cheng Li, Wei-Hong Zhao, Chun-Xia Meng, Hua Ping, Guo-Juan Qin, Shu-Jun Cao, Xiaowei Xi, Qian Zhu, Xiao-Cui Li and Jian Zhang

PLOS ONE, 2014, vol. 9, issue 12, 1-17

Abstract: Objective: To evaluate the association between the risk of ectopic pregnancy (EP) and the use of common contraceptives during the previous and current conception/menstrual cycle. Methods: A multi-center case-control study was conducted in Shanghai. Women diagnosed with EP were recruited as the case group (n = 2,411). Women with intrauterine pregnancy (IUP) (n = 2,416) and non-pregnant women (n = 2,419) were matched as controls at a ratio of 1∶1. Information regarding the previous and current use of contraceptives was collected. Multivariate logistic regression analyses were performed to calculate odds ratios (ORs) and the corresponding 95% confidential intervals (CIs). Results: Previous use of intrauterine devices (IUDs) was associated with a slight risk of ectopic pregnancy (AOR1 = 1.87 [95% CI: 1.48–2.37]; AOR2 = 1.84 [1.49–2.27]), and the risk increased with the duration of previous use (P1 for trend

Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0115031

DOI: 10.1371/journal.pone.0115031

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