Statin Use and Cognitive Function: Population-Based Observational Study with Long-Term Follow-Up

Hanneke Joosten, Sipke T Visser, Marlise E van Eersel, Ron T Gansevoort, Henk J G Bilo, Joris P Slaets and Gerbrand J Izaks

PLOS ONE, 2014, vol. 9, issue 12, 1-15

Abstract: We aimed to evaluate the association between statin use and cognitive function. Cognitive function was measured with the Ruff Figural Fluency Test (RFFT; worst score, 0; best score, 175 points) and the Visual Association Test (VAT; low performance, 0–10; high performance, 11–12 points) in an observational study that included 4,095 community-dwelling participants aged 35–82 years. Data on statin use were obtained from a computerized pharmacy database. Analysis were done for the total cohort and subsamples matched on cardiovascular risk (N = 1232) or propensity score for statin use (N = 3609). We found that a total of 904 participants (10%) used a statin. Statin users were older than non-users: mean age (SD) 61 (10) vs. 52 (11) years (p

Date: 2014
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0115755

DOI: 10.1371/journal.pone.0115755

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