Association of Urinary Cadmium with Mortality in Patients at a Coronary Care Unit

Ching-Wei Hsu, Cheng-Hao Weng, Dan-Tzu Lin-Tan, Pao-Hsien Chu, Tzung-Hai Yen, Kuan-Hsing Chen, Chung-Yin Lin and Wen-Hung Huang

PLOS ONE, 2016, vol. 11, issue 1, 1-12

Abstract: Background: Determine the effect of the day 1 urinary excretion of cadmium (D1-UE-Cd) on mortality of patients admitted to a coronary care unit (CCU). Methods: A total of 323 patients were enrolled in this 6-month study. Urine and blood samples were taken within 24 h after CCU admission. Demographic data, clinical diagnoses, and hospital mortality were recorded. The scores of established systems for prediction of mortality in critically ill patients were calculated. Results: Compared with survivors (n = 289), non-survivors (n = 34) had higher levels of D1-UE-Cd. Stepwise multiple linear regression analysis indicated that D1-UE-Cd was positively associated with pulse rate and level of aspartate aminotransferase, but negatively associated with serum albumin level. Multivariate Cox analysis, with adjustment for other significant variables and measurements from mortality scoring systems, indicated that respiratory rate and D1-UE-Cd were independent and significant predictors of mortality. For each 1 μg/day increase of D1-UE-Cd, the hazard ratio for CCU mortality was 3.160 (95% confidence interval: 1.944–5.136, p

Date: 2016
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0146173

DOI: 10.1371/journal.pone.0146173

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