Interleukin-6 Levels in Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis

Zheng Peng, Yifan Sun, Xiaolan Lv, Hongyu Zhang, Chunming Liu and Shengming Dai

PLOS ONE, 2016, vol. 11, issue 2, 1-14

Abstract: Background: The change of serum interleukin-6(IL-6) levels in women with polycystic ovary syndrome (PCOS), as well as the relations between IL-6 levels and body mass index (BMI), insulin resistance(IR) and androgen status of PCOS patients, are not fully understood. Methods: A literature search was performed in October 2015 using PubMed, Embase and the Cochrane Library databases to identify studies. Random-effects model was used to estimate the standardized mean differences (SMDs) with 95% confidence intervals (CIs). Results: Twenty articles with 25 case-control studies included 1618 women (922 PCOS patients and 696 controls) were included in this study. IL-6 levels in controls were significantly lower than that of PCOS patients (SMD = 0.78, 95%CI = 0.41–1.16, P

Date: 2016
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0148531

DOI: 10.1371/journal.pone.0148531

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