Electrophysiological Rotor Ablation in In-Silico Modeling of Atrial Fibrillation: Comparisons with Dominant Frequency, Shannon Entropy, and Phase Singularity

Minki Hwang, Jun-Seop Song, Young-Seon Lee, Changyong Li, Eun Bo Shim and Hui-Nam Pak

PLOS ONE, 2016, vol. 11, issue 2, 1-15

Abstract: Background: Although rotors have been considered among the drivers of atrial fibrillation (AF), the rotor definition is inconsistent. We evaluated the nature of rotors in 2D and 3D in- silico models of persistent AF (PeAF) by analyzing phase singularity (PS), dominant frequency (DF), Shannon entropy (ShEn), and complex fractionated atrial electrogram cycle length (CFAE-CL) and their ablation. Methods: Mother rotor was spatiotemporally defined as stationary reentries with a meandering tip remaining within half the wavelength and lasting longer than 5 s. We generated 2D- and 3D-maps of the PS, DF, ShEn, and CFAE-CL during AF. The spatial correlations and ablation outcomes targeting each parameter were analyzed. Results: 1. In the 2D PeAF model, we observed a mother rotor that matched relatively well with DF (>9 Hz, 71.0%, p 5.5 Hz, 39.7%, p

Date: 2016
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0149695

DOI: 10.1371/journal.pone.0149695

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