Altered Cerebellar White Matter Integrity in Patients with Mild Traumatic Brain Injury in the Acute Stage

Zhongqiu Wang, Wenzhong Wu, Yongkang Liu, Tianyao Wang, Xiao Chen, Jianhua Zhang, Guoxing Zhou and Rong Chen

PLOS ONE, 2016, vol. 11, issue 3, 1-13

Abstract: Background and Purpose: Imaging studies of traumatic brain injury demonstrate that the cerebellum is often affected. We aim to examine fractional anisotropy alteration in acute-phase mild traumatic brain injury patients in cerebellum-related white matter tracts. Materials and Methods: This prospective study included 47 mild traumatic brain injury patients in the acute stage and 37 controls. MR imaging and neurocognitive tests were performed in patients within 7 days of injury. White matter integrity was examined by using diffusion tensor imaging. We used three approaches, tract-based spatial statistics, graphical-model-based multivariate analysis, and region-of-interest analysis, to detect altered cerebellar white matter integrity in mild traumatic brain injury patients. Results: Results from three analysis methods were in accordance with each other, and suggested fractional anisotropy in the middle cerebellar peduncle and the pontine crossing tract was changed in the acute-phase mild traumatic brain injury patients, relative to controls (adjusted p-value

Date: 2016
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0151489

DOI: 10.1371/journal.pone.0151489

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