Risk Alleles in/near ADCY5, ADRA2A, CDKAL1, CDKN2A/B, GRB10, and TCF7L2 Elevate Plasma Glucose Levels at Birth and in Early Childhood: Results from the FAMILY Study

Zahra N Sohani, Sonia S Anand, Sebastien Robiou-du-Pont, Katherine M Morrison, Sarah D McDonald, Stephanie A Atkinson, Koon K Teo and David Meyre

PLOS ONE, 2016, vol. 11, issue 4, 1-8

Abstract: Background: Metabolic abnormalities that lead to type 2 diabetes mellitus begin in early childhood. Objectives: We investigate whether common genetic variants identified in adults have an effect on glucose in early life. Methods: 610 newborns, 463 mothers, and 366 fathers were included in the present study. Plasma glucose and anthropometric characteristics were collected at birth, 3, and 5 years. After quality assessment, 37 SNPs, which have demonstrated an association with fasting plasma glucose at the genome-wide threshold in adults, were studied. Quantitative trait disequilibrium tests and mixed-effects regressions were conducted to estimate an effect of the SNPs on glucose. Results: Risk alleles for 6 loci increased glucose levels from birth to 5 years of age (ADCY5, ADRA2A, CDKAL1, CDKN2A/B, GRB10, and TCF7L2, 4.85x10-3 ≤ P ≤ 4.60x10-2). Together, these 6 SNPs increase glucose by 0.05 mmol/L for each risk allele in a genotype score (P = 6.33x10-5). None of the associations described in the present study have been reported previously in early childhood. Conclusion: Our data support the notion that a subset of loci contributing to plasma glucose variation in adults has an effect at birth and in early life.

Date: 2016
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0152107 (text/html)
https://journals.plos.org/plosone/article/file?id= ... 52107&type=printable (application/pdf)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0152107

DOI: 10.1371/journal.pone.0152107

Access Statistics for this article

More articles in PLOS ONE from Public Library of Science
Bibliographic data for series maintained by plosone ().