High Pretreatment D-Dimer Levels Correlate with Adverse Clinical Features and Predict Poor Survival in Patients with Natural Killer/T-Cell Lymphoma

Xi-wen Bi, Liang Wang, Wen-wen Zhang, Peng Sun, Shu-mei Yan, Pan-pan Liu, Zhi-ming Li and Wen-qi Jiang

PLOS ONE, 2016, vol. 11, issue 3, 1-12

Abstract: Pretreatment plasma D-dimer levels have been reported to predict survival in several types of malignancies. The aim of this study was to evaluate the prognostic value of D-dimer levels in patients with newly diagnosed natural killer/T-cell lymphoma (NKTCL). The cut-off value of D-dimer to predict survival was set as 1.2 μg/mL based on the receiver operating curve analysis. Patients with a D-dimer level ≥ 1.2 μg/mL had significantly more adverse clinical features, including poor performance status, advanced stage diseases, B symptoms, elevated serum lactic dehydrogenase levels, involvement of regional lymph nodes, more extranodal diseases, and higher International Prognostic Index and natural killer/T-cell lymphoma prognostic index scores. A D-dimer level ≥ 1.2 μg/mL was significantly associated with inferior 3-year overall survival (OS, 13.0 vs. 68.5%, P

Date: 2016
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0152842

DOI: 10.1371/journal.pone.0152842

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