Chronic Kidney Disease and the Risk of New-Onset Atrial Fibrillation: A Meta-Analysis of Prospective Cohort Studies

Weifeng Shang, Lixi Li, Shuai Huang, Rui Zeng, Liu Huang, Shuwang Ge and Gang Xu

PLOS ONE, 2016, vol. 11, issue 5, 1-10

Abstract: Objective: Recent epidemiological evidence indicates an association between chronic kidney disease (CKD) and the risk of new-onset atrial fibrillation (AF), but the results are inconclusive. This meta-analysis examined the association between CKD and new-onset AF. Methods: PubMed, EMBASE, the Cochrane Collaboration and the reference lists of relevant articles were searched to identify eligible studies. The random effect model was used to calculate the overall multivariable-adjusted hazard ratio (HR) with its corresponding 95% confidence interval (CI). Associations were tested in subgroups of study characteristics and study quality criteria. We also performed sensitivity analyses and assessments of publishing bias. Results: Seven prospective cohort studies (n = 400,189 participants) were included in this meta-analysis. Pooled results suggested that CKD was associated with an increased adjusted risk estimate for new-onset AF (HR, 1.47; 95% CI, 1.21–1.78), with significant heterogeneity between these studies (I2 = 79.7%, P

Date: 2016
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0155581

DOI: 10.1371/journal.pone.0155581

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