A Tubular Biomaterial Construct Exhibiting a Negative Poisson’s Ratio

Jin Woo Lee, Pranav Soman, Jeong Hun Park, Shaochen Chen and Dong-Woo Cho

PLOS ONE, 2016, vol. 11, issue 5, 1-14

Abstract: Developing functional small-diameter vascular grafts is an important objective in tissue engineering research. In this study, we address the problem of compliance mismatch by designing and developing a 3D tubular construct that has a negative Poisson’s ratio νxy (NPR). NPR constructs have the unique ability to expand transversely when pulled axially, thereby resulting in a highly-compliant tubular construct. In this work, we used projection stereolithography to 3D-print a planar NPR sheet composed of photosensitive poly(ethylene) glycol diacrylate biomaterial. We used a step-lithography exposure and a stitch process to scale up the projection printing process, and used the cut-missing rib unit design to develop a centimeter-scale NPR sheet, which was rolled up to form a tubular construct. The constructs had Poisson’s ratios of -0.6 ≤ νxy ≤ -0.1. The NPR construct also supports higher cellular adhesion than does the construct that has positive νxy. Our NPR design offers a significant advance in the development of highly-compliant vascular grafts.

Date: 2016
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0155681

DOI: 10.1371/journal.pone.0155681

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