Organ Dose and Attributable Cancer Risk in Lung Cancer Screening with Low-Dose Computed Tomography

Natalia Saltybaeva, Katharina Martini, Thomas Frauenfelder and Hatem Alkadhi

PLOS ONE, 2016, vol. 11, issue 5, 1-11

Abstract: Purpose: Lung cancer screening with CT has been recently recommended for decreasing lung cancer mortality. The radiation dose of CT, however, must be kept as low as reasonably achievable for reducing potential stochastic risks from ionizing radiation. The purpose of this study was to calculate individual patients’ lung doses and to estimate cancer risks in low-dose CT (LDCT) in comparison with a standard dose CT (SDCT) protocol. Materials and Methods: This study included 47 adult patients (mean age 63.0 ± 5.7 years) undergoing chest CT on a third-generation dual-source scanner. 23/47 patients (49%) had a non-enhanced chest SDCT, 24 patients (51%) underwent LDCT at 100 kVp with spectral shaping at a dose equivalent to a chest x-ray. 3D-dose distributions were obtained from Monte Carlo simulations for each patient, taking into account their body size and individual CT protocol. Based on the dose distributions, patient-specific lung doses were calculated and relative cancer risk was estimated according to BEIR VII recommendations. Results: As compared to SDCT, the LDCT protocol allowed for significant organ dose and cancer risk reductions (p

Date: 2016
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0155722

DOI: 10.1371/journal.pone.0155722

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