Lack of Significant Effects of Chlamydia trachomatis Infection on Cervical Adenocarcinoma Risk: Nested Case-Control Study

Vitaly Smelov, Tarik Gheit, Karin Sundström, Alexander Ploner, Sandrine McKay-Chopin, Carina Eklund, Massimo Tommasino and Joakim Dillner

PLOS ONE, 2016, vol. 11, issue 5, 1-5

Abstract: Background: A role of Chlamydia trachomatis in HPV-induced cervical carcinogenesis has been reported for cervical cancer but studies on cervical adenocarcinoma are limited. Methods: A total of 1,553 cervical smears taken up to 26 years before diagnosis in a large population-based nested case-control study of cervical adenocarcinoma (AC, 132 cases with matched controls), and adenocarcinoma in situ (AIS, 159 cases with matched controls) were tested for C. trachomatis and HPV DNA by a type-specific PCR bead-based multiplex genotyping (TS-MPG) assay. Results: Only 1.7% of samples were positive for C. trachomatis, with no significant differences between AC/AIS cases and controls. HPV-positivity was detected in 49.3% of C. trachomatis-negative and 65.4% C. trachomatis-positive samples, respectively. Conclusions: A large prospective study did not find any risk for cervical adenocarcinoma and/or AIS conferred by C. trachomatis infection. Impact: C. trachomatis appears not to be involved in cervical adenocarcinomas.

Date: 2016
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0156215

DOI: 10.1371/journal.pone.0156215

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