Investigation of NS3 Protease Resistance-Associated Variants and Phenotypes for the Prediction of Treatment Response to HCV Triple Therapy

Julia Dietz, Daniel Rupp, Simone Susser, Johannes Vermehren, Kai-Henrik Peiffer, Natalie Filmann, Dimitra Bon, Thomas Kuntzen, Stefan Mauss, Georgios Grammatikos, Dany Perner, Caterina Berkowski, Eva Herrmann, Stefan Zeuzem, Ralf Bartenschlager and Christoph Sarrazin

PLOS ONE, 2016, vol. 11, issue 6, 1-17

Abstract: Triple therapy of chronic hepatitis C virus (HCV) infection with boceprevir (BOC) or telaprevir (TVR) leads to virologic failure in many patients which is often associated with the selection of resistance-associated variants (RAVs). These resistance profiles are of importance for the selection of potential rescue treatment options. In this study, we sequenced baseline NS3 RAVs population-based and investigated the sensitivity of NS3 phenotypes in an HCV replicon assay together with clinical factors for a prediction of treatment response in a cohort of 165 German and Swiss patients treated with a BOC or TVR-based triple therapy. Overall, the prevalence of baseline RAVs was low, although the frequency of RAVs was higher in patients with virologic failure compared to those who achieved a sustained virologic response (SVR) (7% versus 1%, P = 0.06). The occurrence of RAVs was associated with a resistant NS3 quasispecies phenotype (P

Date: 2016
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0156731

DOI: 10.1371/journal.pone.0156731

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