Changes in the Cytoplasmic Composition of Amino Acids and Proteins Observed in Staphylococcus aureus during Growth under Variable Growth Conditions Representative of the Human Wound Site

Mousa M Alreshidi, R Hugh Dunstan, Johan Gottfries, Margaret M Macdonald, Marcus J Crompton, Ching-Seng Ang, Nicholas A Williamson and Tim K Roberts

PLOS ONE, 2016, vol. 11, issue 7, 1-19

Abstract: Staphylococcus aureus is an opportunistic pathogen responsible for a high proportion of nosocomial infections. This study was conducted to assess the bacterial responses in the cytoplasmic composition of amino acids and ribosomal proteins under various environmental conditions designed to mimic those on the human skin or within a wound site: pH6-8, temperature 35–37°C, and additional 0–5% NaCl. It was found that each set of environmental conditions elicited substantial adjustments in cytoplasmic levels of glutamic acid, aspartic acid, proline, alanine and glycine (P

Date: 2016
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0159662

DOI: 10.1371/journal.pone.0159662

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