Cross-Species Analysis of Gene Expression and Function in Prefrontal Cortex, Hippocampus and Striatum

Wei Chen, Xiayu Xia, Nan Song, Ying Wang, Hua Zhu, Wei Deng, Qi Kong, Xianmin Pan and Chuan Qin

PLOS ONE, 2016, vol. 11, issue 10, 1-18

Abstract: Background: Mouse has been extensively used as a tool for investigating the onset and development of human neurological disorders. As a first step to construct a transgenic mouse model of human brain lesions, it is of fundamental importance to clarify the similarity and divergence of genetic background between non-diseased human and mouse brain tissues. Methods: We systematically compared, based on large scale integrated microarray data, the transcriptomes of three anatomically distinct brain regions; prefrontal cortex (PFC), hippocampus (HIP) and striatum (STR), across human and mouse. The widely used DAVID web server was used to decipher the biological functions of the highly expressed genes that were identified using a previously reported approach. Venn analysis was used to depict the overlapping ratios of the notably enriched biological process (BP) terms (one-tailed Fisher’s exact test and Benjamini correction; adjusted p

Date: 2016
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0164295

DOI: 10.1371/journal.pone.0164295

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