Statin Use and Self-Reported Hindering Muscle Complaints in Older Persons: A Population Based Study

Milly A van der Ploeg, Rosalinde K E Poortvliet, Sophie C E van Blijswijk, Wendy P J den Elzen, Petra G van Peet, Wouter de Ruijter, Jeanet W Blom and Jacobijn Gussekloo

PLOS ONE, 2016, vol. 11, issue 12, 1-9

Abstract: Purpose: Statins are widely used by older persons in primary and secondary prevention of cardiovascular disease. Although serious adverse events are rare, many statin users report mild muscle pain and/or muscle weakness. It’s unclear what impact statins exert on a patient’s daily life. Research on statin related side effects in older persons is relatively scarce. We therefore investigated the relation between statin use and self-reported hindering muscle complaints in older persons in the general population. Methods: The present research was performed within the Integrated Systematic Care for Older Persons (ISCOPE) study in the Netherlands (Netherlands trial register, NTR1946). All registered adults aged ≥ 75 years from 59 participating practices (n = 12,066) were targeted. Information about the medical history and statin use at baseline and after 9 months was available for 4355 participants from the Electronic Patient Records of the general practitioners. In the screening questionnaire at baseline we asked participants: ‘At the moment, which health complaints limit you the most in your day-to-day life?’ Answers indicating muscle or musculoskeletal complaints were coded as such. No specific questions about muscle complaints were asked. Results: The participants had a median age of 80.3 (IQR 77.6–84.4) years, 60.8% were female and 28.5% had a history of CVD. At baseline 29% used a statin. At follow-up, no difference was found in the prevalence of self-reported hindering muscle complaints in statin users compared to non-statin users (3.3% vs. 2.5%, OR 1.39, 95% CI 0.94–2.05; P = 0.98). Discontinuation of statin use during follow-up was independent of self-reported hindering muscle complaints. Conclusion: Based on the present findings, prevalent statin use in this community-dwelling older population is not associated with self-reported hindering muscle complaints; however, the results might be different for incident users.

Date: 2016
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0166857

DOI: 10.1371/journal.pone.0166857

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