Impact of Oral Treatment on Physical Function in Older Patients Hospitalized for Heart Failure: A Randomized Clinical Trial

Kazutaka Ueda, Masashi Kasao, Motoaki Shimamura, Hironori Haruta, Shuya Nitta, Mitsunobu Kaneko, Yukari Uemura, Hiroyuki Morita, Issei Komuro and Tetsuro Shirai

PLOS ONE, 2016, vol. 11, issue 12, 1-12

Abstract: Background: Frailty is a characteristic of older patients with heart failure, who undergo functional decline during hospitalization. At present, continuous intravenous infusion of diuretics is widely used for the treatment of hospitalized patients with heart failure. In this prospective, randomized, open-label controlled trial, we tested whether an early switch from continuous intravenous infusion therapy to oral treatment with diuretics prevents functional decline in patients hospitalized for heart failure. Methods: A total of 59 patients hospitalized for heart failure were randomized to either continuous intravenous infusion (n = 30) or oral medication (n = 29) within 48 h of admission. The primary outcome was the Barthel index, a universally utilized scale to assess the functional status of patients in their activities of daily living, assessed at 10 days. Secondary outcomes included the number of daily steps counted using pedometers and average hospital costs. Results: Barthel index scores were significantly higher in the oral medication group than in the intravenous group (78.1 ± 20.8 vs. 59.6 ± 34.2, P = 0.029). The number of daily steps was significantly higher in the oral treatment group relative to the intravenous group (P

Date: 2016
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0167933

DOI: 10.1371/journal.pone.0167933

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