Effectiveness of betahistine (48 mg/day) in patients with vestibular vertigo during routine practice: The VIRTUOSO study

Vladimir A Parfenov, Volodymyr A Golyk, Eduard I Matsnev, Svetlana V Morozova, Oleg A Melnikov, Ludmila M Antonenko, Elena E Sigaleva, Maksym I Situkho, Olena I Asaulenko, Vasyl I Popovych and Maxim V Zamergrad

PLOS ONE, 2017, vol. 12, issue 3, 1-11

Abstract: Background: Vestibular vertigo is associated with substantially reduced quality of life. Betahistine is effective in improving vertigo-associated symptoms, with longer treatment periods leading to greater improvements; however, it is not known whether these effects persist after treatment cessation. Methods: VIRTUOSO was a prospective, multinational, non-comparative, post-marketing observational programme investigating the effectiveness of betahistine (48 mg/day) and the course of vertigo after the discontinuation of treatment. Patients with vestibular vertigo who were prescribed 48 mg/day betahistine were enrolled in Russia and Ukraine. Treatment duration was up to 2 months, and patients were followed up for 2 months after discontinuation of betahistine. Efficacy endpoints included clinical response (assessed by change in vertigo severity), monthly attack frequency, and physician and patient grading of overall clinical response and improvement of vertigo-associated symptoms. Results: Overall, 309 patients were enrolled and 305 completed the study. Clinical response was rated as good, very good or excellent in 74.1% of patients at end of treatment, with vertigo severity significantly decreased from baseline (p

Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0174114

DOI: 10.1371/journal.pone.0174114

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