Newly identified risk factors for MRSA carriage in The Netherlands

W S N Lekkerkerk, A Haenen, M A B van der Sande, T Leenstra, S de Greeff, A Timen, A Tjon-a-Tsien, J H Richardus, N van de Sande-Bruinsma and M C Vos

PLOS ONE, 2017, vol. 12, issue 11, 1-12

Abstract: Objectives: To elucidate new risk factors for MRSA carriers without known risk factors (MRSA of unknown origin; MUO). These MUO carriers are neither pre-emptively screened nor isolated as normally dictated by the Dutch Search & Destroy policy, thus resulting in policy failure. Methods: We performed a prospective case control study to determine risk factors for MUO acquisition/carriage (Dutch Trial Register: NTR2041). Results: Significant risk factors for MUO in logistic multivariate analysis were antibiotic use in the last twelve months, aOR 8.1 (5.6–11.7), screened as contact in a contact tracing but not detected as a MRSA carrier at that time, aOR 4.3 (2.1–8.8), having at least one foreign parent, aOR 2.4 (1.4–3.9) and receiving ambulatory care, aOR 2.3 (1.4–3.7). Our found risk factors explained 83% of the MUO carriage. Conclusions: Identifying new risk factors for MRSA carriers remains crucial for countries that apply a targeted screening approach as a Search and Destroy policy or as vertical infection prevention measure.

Date: 2017
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0188502

DOI: 10.1371/journal.pone.0188502

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