A Boolean network of the crosstalk between IGF and Wnt signaling in aging satellite cells

Lea Siegle, Julian D Schwab, Silke D Kühlwein, Ludwig Lausser, Stefan Tümpel, Astrid S Pfister, Michael Kühl and Hans A Kestler

PLOS ONE, 2018, vol. 13, issue 3, 1-24

Abstract: Aging is a complex biological process, which determines the life span of an organism. Insulin-like growth factor (IGF) and Wnt signaling pathways govern the process of aging. Both pathways share common downstream targets that allow competitive crosstalk between these branches. Of note, a shift from IGF to Wnt signaling has been observed during aging of satellite cells. Biological regulatory networks necessary to recreate aging have not yet been discovered. Here, we established a mathematical in silico model that robustly recapitulates the crosstalk between IGF and Wnt signaling. Strikingly, it predicts critical nodes following a shift from IGF to Wnt signaling. These findings indicate that this shift might cause age-related diseases.

Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0195126

DOI: 10.1371/journal.pone.0195126

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