Characteristics of non-cardia gastric cancer with a high serum anti-Helicobacter pylori IgG titer and its association with diffuse-type histology

Eun Jeong Gong, Ji Young Lee, Suh Eun Bae, Young Soo Park, Kee Don Choi, Ho June Song, Gin Hyug Lee, Hwoon-Yong Jung, Woo Jin Jeong, Gab Jin Cheon, Jeong Hwan Yook and Byung Sik Kim

PLOS ONE, 2018, vol. 13, issue 4, 1-11

Abstract: Background: Data on implications of a high positive titer of serum anti-Helicobacter pylori antibody on gastric cancer (GC) is limited. This study aimed to investigate the characteristics of GC with a high serum anti-H. pylori IgG (Hp-IgG) titer, and its association with diffuse-type GC. Methods: We analyzed clinical and histological characteristics of 917 non-cardia GC patients who underwent gastrectomy. H. pylori infection was determined serologically by measuring Hp-IgG titer with immunoassay. Seropositive patients were divided into three groups (low-positive, mid-positive, and high-positive) according to the Hp-IgG titer value. Tumors were classified according to the Lauren criteria as diffuse or intestinal types. Results: The median age of the patients was 59.0 years, and 33.8% were female. The patents were grouped as follows: seronegative, 188 (20.5%); low-positive, 288 (31.4%); mid-positive, 290 (31.6%); and high-positive 151 (16.5%). The high-positive group was significantly younger (median age, 55.0 years), with a higher proportion of female (45.0%) and non-smokers (58.9%). The proportion of diffuse-type GC increased in the order low-, mid-, and high-positive groups (p

Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0195264

DOI: 10.1371/journal.pone.0195264

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