A novel echocardiographic hemodynamic index for predicting outcome of aortic stenosis patients following transcatheter aortic valve replacement

Altayyeb Yousef, Benjamin Hibbert, Joshua Feder, Jordan Bernick, Juan Russo, Zachary MacDonald, Christopher Glover, Alexander Dick, Munir Boodhwani, Buu-Khanh Lam, Marc Ruel, Marino Labinaz and Ian G Burwash

PLOS ONE, 2018, vol. 13, issue 4, 1-15

Abstract: Objective: Transcatheter aortic valve replacement (TAVR) reduces left ventricular (LV) afterload and improves prognosis in aortic stenosis (AS) patients. However, LV afterload consists of both valvular and arterial loads, and the benefits of TAVR may be attenuated if the arterial load dominates. We proposed a new hemodynamic index, the Relative Valve Load (RVL), a ratio of mean gradient (MG) and valvuloarterial impedance (Zva), to describe the relative contribution of the valvular load to the global LV load, and examined whether RVL predicted patient outcome following TAVR. Methods: A total of 258 patients with symptomatic severe AS (indexed aortic valve area (AVA) 0.75cm2, %SWL≤25% and Zva>5mmHg/ml/m2 despite equivalent or better sensitivity. In multivariable Cox analysis, RVL≤7.95ml/m2 was an independent predictor of all cause mortality (HR 3.2, CI 1.8–5.9; p

Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0195641

DOI: 10.1371/journal.pone.0195641

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