Bone mineral density and vertebral fractures in patients with systemic lupus erythematosus: A systematic review and meta-regression

Claudia Mendoza-Pinto, Adriana Rojas-Villarraga, Nicolás Molano-González, Erick A Jiménez-Herrera, María de la Luz León-Vázquez, Álvaro Montiel-Jarquín, Mario García-Carrasco and Ricard Cervera

PLOS ONE, 2018, vol. 13, issue 6, 1-15

Abstract: Background: Observational studies have indicated a high but heterogeneous prevalence of low bone mineral density (BMD) and vertebral fractures (VF) in patients with systemic lupus erythematosus (SLE). Therefore, the objectives of this systematic review and meta-regression were: 1) to compare BMD between SLE patients and healthy controls and 2) to evaluate the relationship between BMD and glucocorticoid therapy and VF in SLE patients. Methods and findings: Articles were identified from electronic databases (PubMed, Embase, VHL, SciELO and the Cochrane Library). Prospective longitudinal and cross-sectional studies were considered for review. We evaluated the quality of the evidence included using the Oxford Centre for evidence-based medicine (EBM) Levels of Evidence. In total, 38 articles were identified and analyzed (3442 SLE cases and 6198 controls) in the analysis of BMD (9232 women and 408 men). There were significant differences in mean BMD between SLE patients and controls. BMD mean difference in cases/controls: -0.0566 95% CI (-0.071, -0.0439; p =

Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0196113

DOI: 10.1371/journal.pone.0196113

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