Virtual reality method to analyze visual recognition in mice

Brent Kevin Young, Jayden Nicole Brennan, Ping Wang and Ning Tian

PLOS ONE, 2018, vol. 13, issue 5, 1-14

Abstract: Behavioral tests have been extensively used to measure the visual function of mice. To determine how precisely mice perceive certain visual cues, it is necessary to have a quantifiable measurement of their behavioral responses. Recently, virtual reality tests have been utilized for a variety of purposes, from analyzing hippocampal cell functionality to identifying visual acuity. Despite the widespread use of these tests, the training requirement for the recognition of a variety of different visual targets, and the performance of the behavioral tests has not been thoroughly characterized. We have developed a virtual reality behavior testing approach that can essay a variety of different aspects of visual perception, including color/luminance and motion detection. When tested for the ability to detect a color/luminance target or a moving target, mice were able to discern the designated target after 9 days of continuous training. However, the quality of their performance is significantly affected by the complexity of the visual target, and their ability to navigate on a spherical treadmill. Importantly, mice retained memory of their visual recognition for at least three weeks after the end of their behavioral training.

Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0196563

DOI: 10.1371/journal.pone.0196563

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