Survival outcomes post percutaneous coronary intervention: Why the hype about stent type? Lessons from a healthcare system in India

Bhanu Duggal, Jyothi Subramanian, Mona Duggal, Pushpendra Singh, Meeta Rajivlochan, Sujata Saunik, Koundinya Desiraju, Archana Avhad, Usha Ram, Sayan Sen and Anurag Agrawal

PLOS ONE, 2018, vol. 13, issue 5, 1-14

Abstract: A prospective, multicenter study was initiated by the Government of Maharashtra, India, to determine predictors of long-term outcomes of percutaneous coronary intervention (PCI) for coronary artery disease, and to compare the effectiveness of drug-eluting stents (DESs) and bare-metal stents (BMSs) in patients undergoing PCI under government-funded insurance. The present analysis included 4595 patients managed between August 2012 and November 2016 at any of 110 participating centers. Using the classical multivariable regression and propensity-matching approach, we found age to be the most important predictor of 1-year mortality and target lesion revascularization at 1 year post-PCI. However, using machine learning methods to account for unmeasured confounders and bias in this large observational study, we determined total stent length and number of stents deployed as the most important predictors of 1-year survival, followed by age and employment status. The unadjusted death rates were 5.0% and 3.8% for the BMS and DES groups, respectively (p = 0.185, log-rank test). The rate of re-hospitalization (p

Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0196830

DOI: 10.1371/journal.pone.0196830

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