A method for age-matched OCT angiography deviation mapping in the assessment of disease- related changes to the radial peripapillary capillaries

Alexander Pinhas, Rachel Linderman, Shelley Mo, Brian D Krawitz, Lawrence S Geyman, Joseph Carroll, Richard B Rosen and Toco Y Chui

PLOS ONE, 2018, vol. 13, issue 5, 1-16

Abstract: Purpose: To present a method for age-matched deviation mapping in the assessment of disease-related changes to the radial peripapillary capillaries (RPCs). Methods: We reviewed 4.5x4.5mm en face peripapillary OCT-A scans of 133 healthy control eyes (133 subjects, mean 41.5 yrs, range 11–82 yrs) and 4 eyes with distinct retinal pathologies, obtained using spectral-domain optical coherence tomography angiography. Statistical analysis was performed to evaluate the impact of age on RPC perfusion densities. RPC density group mean and standard deviation maps were generated for each decade of life. Deviation maps were created for the diseased eyes based on these maps. Large peripapillary vessel (LPV; noncapillary vessel) perfusion density was also studied for impact of age. Results: Average healthy RPC density was 42.5±1.47%. ANOVA and pairwise Tukey-Kramer tests showed that RPC density in the ≥60yr group was significantly lower compared to RPC density in all younger decades of life (p

Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0197062

DOI: 10.1371/journal.pone.0197062

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