Association of cerebral oxygenation with estimated glomerular filtration rate and cognitive function in chronic kidney disease patients without dialysis therapy

Haruhisa Miyazawa, Susumu Ookawara, Kiyonori Ito, Yuichiro Ueda, Katsunori Yanai, Hiroki Ishii, Yuko Mutsuyoshi, Taisuke Kitano, Mitsutoshi Shindo, Akinori Aomatsu, Keiji Hirai, Taro Hoshino and Yoshiyuki Morishita

PLOS ONE, 2018, vol. 13, issue 6, 1-11

Abstract: Background: A decline in estimated glomerular filtration rate (eGFR) is reportedly associated with increased prevalence rates of cognitive impairment. However, data concerning the association between the cerebral saturation of oxygen (rSO2) and cognitive function of patients with chronic kidney disease (CKD) is limited. This study aimed to (i) elucidate the clinical factors associating with cerebral rSO2 and (ii) investigate the association between cerebral rSO2 and cognitive assessment in CKD patients. Methods: A total of 40 CKD patients not requiring dialysis (26 men and 14 women; mean age, 61.0 ± 2.7 years) were recruited. The numbers of patients at each CKD stage were as follows: G1, 5; G2, 8; G3a, 6; G3b, 5; G4, 11; and G5, 5. Cerebral rSO2 was monitored at the forehead using the oxygen saturation monitor INVOS 5100C. The cognitive function of each patient was confirmed using the Mini-Mental State Examination (MMSE). Results: Cerebral rSO2 levels were significantly higher in CKD patients than in hemodialysis patients (63.8 ± 1.5% vs. 44.9 ± 2.2%, p

Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0199366

DOI: 10.1371/journal.pone.0199366

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