Exploring C-peptide loss in type 1 diabetes using growth curve analysis

Rachel E J Besser, Johnny Ludvigsson, Peter C Hindmarsh and Tim J Cole

PLOS ONE, 2018, vol. 13, issue 7, 1-11

Abstract: Objectives: C-peptide (CP) loss in type 1 diabetes (T1D) is highly variable, and factors influencing it are poorly understood. We modelled CP values in T1D patients from diagnosis for up to 6 years, treating the serial data as growth curves plotted against time since diagnosis. The aims were to summarise the pattern of CP loss (i.e. growth curve shape) in individual patients in simple terms, and to identify baseline characteristics that predict this pattern in individuals. Materials and methods: Between 1976 and 2011, 442 T1D patients initially aged

Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0199635

DOI: 10.1371/journal.pone.0199635

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