Association of high titers of anti-carbamylated protein antibodies with decreased bone mineral density in early arthritis patients

Cristina Regueiro, Ana M Ortiz, Maria Dolores Boveda, Santos Castañeda, Isidoro Gonzalez-Alvaro and Antonio Gonzalez

PLOS ONE, 2018, vol. 13, issue 8, 1-12

Abstract: Rheumatoid arthritis (RA) has a negative impact on bone that is partly mediated by anti-citrullinated proteins antibodies (ACPA). These antibodies are associated with erosions, and with juxta-articular and systemic bone loss. Other RA autoantibodies, the anti-carbamylated protein antibodies (anti-CarPA), are independently associated with erosions. However, we do not know if they are also associated with juxta-articular and systemic bone loss. Here, we have addressed this question with data from 548 early arthritis (EA) patients. Bone mineral density (BMD) was assessed by dual-energy x-ray absorptiometry at the lumbar spine (LS), total hip (TH) and metacarpophalangeal joints (MCP). The 25.9% anti-CarPA positive patients did not show significant differences in BMD Z-scores with the negative patients. Nevertheless, this result was due to the similarity between negative and low-positive (below the median of the positive) patients, whereas the high-positive patients showed significant decrease of BMD at LS (β = -0.39, p = 0.01) and TH (β = -0.30, p = 0.02); but not at the juxta-articular bone of MCP. Given the overlap between anti-CarPA and ACPA, we included the two autoantibodies in an analysis that showed significantly lower BMD Z-scores at LS and TH (p

Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0202583

DOI: 10.1371/journal.pone.0202583

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