Prevalence and geographical variation of Factor V Leiden in patients with cerebral venous thrombosis: A meta-analysis

Xinyuan Li, Li Cui, Yunbo Li, Lijun Zhu, Chenglin Wang, Jing Liu and Shaokuan Fang

PLOS ONE, 2018, vol. 13, issue 8, 1-15

Abstract: Background: Previous results regarding the prevalence of Factor V Leiden (FVL) in patients with cerebral venous thrombosis (CVT) varied remarkably. Therefore, we performed a meta-analysis to evaluate the potential association between FVL and CVT. Methods: The PubMed, Embase, Cochrane Central Register of Controlled Trials, and Web of Science were searched for relevant case-control studies. The data were pooled for analysis of the association between FVL and CVT with a random-effects model. Subgroup and sensitivity analyses were performed to evaluate the robustness of the results. Publication bias was assessed by funnel plot and the Egger’s test. Results: A total of 39 case-control studies including 1807 cases of CVT and 7699 control cases were included. FVL was more common in patients with CVT (195/1822) than in controls(369/7795), [odds ratio(OR) = 2.70, 95% confidence interval(CI) 2.16–3.38, P

Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0203309

DOI: 10.1371/journal.pone.0203309

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