Hepatobiliary scintigraphy allows the evaluation of short-term functional toxicity of liver stereotactic body radiotherapy: Results of a pilot study

Berardino De Bari, Thomas Breuneval, Michele Zeverino, Sarah Godin, Letizia Deantonio, Christine Geldhof, Jean Bourhis, Nicklaus Schaefer, Raphaël Moeckli, John Prior and Mahmut Ozsahin

PLOS ONE, 2018, vol. 13, issue 10, 1-8

Abstract: Purpose: To study the potential of (99m)Tc-Mebrofenin hepatobiliary scintigraphy (HBS) in identifying the short-term variations of liver function after stereotactic body radiotherapy (SBRT) for liver cancers. Material and methods: We treated with SBRT 3 patients (pts) affected by a cholangiocarcinoma and 3 patient presenting liver metastases (3x15 Gy, 4 pts; 5x8 Gy, 1 pt; 6x5 Gy, 1 pt). All patients received HBS before and 3 months after SBRT, which were co-registered with the simulation CT-scan. Structures corresponding to isodoses from 10–90 Gy were created, with intervals of 10 Gy. Finally, the variations of the mean activity (MBq) in each isodose structure have been calculated. Then, a linear regression analysis was performed. Results: We showed a linear reduction of the activity, significantly related to the delivered dose (p

Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0204013

DOI: 10.1371/journal.pone.0204013

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