Tracking intracellular dynamics through extracellular measurements

Franz Hamilton, Tyrus Berry and Timothy Sauer

PLOS ONE, 2018, vol. 13, issue 10, 1-13

Abstract: Extracellular recordings of neuronal cells are frequently a part of in vitro and in vivo experimental studies as a means of monitoring network-level dynamics. Their connections to intracellular dynamics are not well understood. Single-unit recordings are a more direct way to measure intracellular dynamics, but are typically difficult and expensive. On the other hand, simple differential equations models exist for single neurons. In this article, we apply a recent advance in data assimilation theory, designed to correct bias in general observation functions, toward the reconstruction of model-based intracellular dynamics from extracellular recordings.

Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0205031

DOI: 10.1371/journal.pone.0205031

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