Obstructive sleep apnea in patients surviving acute hypercapnic respiratory failure is best predicted by static hyperinflation

Dan Adler, Elise Dupuis-Lozeron, Jean Paul Janssens, Paola M Soccal, Frédéric Lador, Laurent Brochard and Jean-Louis Pépin

PLOS ONE, 2018, vol. 13, issue 10, 1-11

Abstract: Rationale: Acute hypercapnic respiratory failure (AHRF) treated with non-invasive ventilation in the ICU is frequently caused by chronic obstructive pulmonary disease (COPD) exacerbations and obesity-hypoventilation syndrome, the latter being most often associated with obstructive sleep apnea. Overlap syndrome (a combination of COPD and obstructive sleep apnea) may represent a major burden in this population, and specific diagnostic pathways are needed to improve its detection early after ICU discharge. Objectives: To evaluate whether pulmonary function tests can identify a high probability of obstructive sleep apnea in AHRF survivors and outperform common screening questionnaires to identify the disorder. Methods: Fifty-three patients surviving AHRF (31 males; median age 67 years (interquartile range: 62–74) participated in the study. Anthropometric data were recorded and body plethysmography was performed 15 days after ICU discharge. A sleep study was performed 3 months after ICU discharge. Results: The apnea-hypopnea index was negatively associated with static hyperinflation as measured by the residual volume to total lung capacity ratio in the % of predicted (coefficient = -0.64; standard error 0.17; 95% CI -0.97 to -0.31; p

Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0205669

DOI: 10.1371/journal.pone.0205669

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