A meta-analysis on the role of pleiotrophin (PTN) as a prognostic factor in cancer

Jiupeng Zhou, Yuanli Yang, Yongfeng Zhang, Heng Liu and Quanli Dou

PLOS ONE, 2018, vol. 13, issue 11, 1-14

Abstract: Background: Some researchers reported that pleiotrophin (PTN) is associated with the development and metastasis of various tumors and it is a poor prognostic factor for the tumor patients. However, the results of other researches are inconsistent with them. It is obliged to do a meta-analysis to reach a definite conclusion. Methods: The published studies relevant to PTN were searched in the databases including PubMed, Embase and Web of Science until March 20, 2018. A meta-analysis was conducted to evaluate the role of PTN in clinicopathological characteristics and overall survival (OS) of cancer patients. Results: Our meta-analysis indicated that the high expression of PTN was remarkably associated with advanced TNM stage (OR = 2.79, 95%CI: 1.92–4.06, P

Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0207473

DOI: 10.1371/journal.pone.0207473

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