A variant within the FTO confers susceptibility to diabetic nephropathy in Japanese patients with type 2 diabetes

Makiko Taira, Minako Imamura, Atsushi Takahashi, Yoichiro Kamatani, Toshimasa Yamauchi, Shin-ichi Araki, Nobue Tanaka, Natalie R van Zuydam, Emma Ahlqvist, Masao Toyoda, Tomoya Umezono, Koichi Kawai, Masahito Imanishi, Hirotaka Watada, Daisuke Suzuki, Hiroshi Maegawa, Tetsuya Babazono, Kohei Kaku, Ryuzo Kawamori, The SUMMIT Consortium, Leif C Groop, Mark I McCarthy, Takashi Kadowaki and Shiro Maeda

PLOS ONE, 2018, vol. 13, issue 12, 1-13

Abstract: To explore novel genetic loci for diabetic nephropathy, we performed genome-wide association studies (GWAS) for diabetic nephropathy in Japanese patients with type 2 diabetes. We analyzed the association of 5,768,242 single nucleotide polymorphisms (SNPs) in Japanese patients with type 2 diabetes, 2,380 nephropathy cases and 5,234 controls. We further performed GWAS for diabetic nephropathy using independent Japanese patients with type 2 diabetes, 429 cases and 358 controls and the results of these two GWAS were combined with an inverse variance meta-analysis (stage-1), followed by a de novo genotyping for the candidate SNP loci (p

Date: 2018
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0208654

DOI: 10.1371/journal.pone.0208654

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