Changes in QTc interval in long-term hemodialysis patients

Yoshihiro Matsumoto, Yasuo Mori, Shinji Kageyama, Kazuo Arihara, Hidemaro Sato, Kijun Nagata, Yasushi Shimada, Yohichi Nojima, Koichiro Iguchi and Toshikazu Sugiyama

PLOS ONE, 2019, vol. 14, issue 1, 1-10

Abstract: Background: Cardiovascular diseases, including sudden cardiac death (SCD), are the leading cause of death in hemodialysis (HD) patients. A prolonged QT interval on the electrocardiogram (ECG) is a risk factor for SCD in HD patients. This study investigated whether the heart rate-corrected QT (QTc) interval becomes prolonged along with dialysis vintage. Methods: A total of 102 HD patients were retrospectively studied. Their ECG data were analyzed at 1, 4, and 7 years after HD initiation. The control group comprised 68 age-matched individuals who had normal renal function and two available ECG reports at an interval of more than 4 years. QTc was measured according to the Bazett formula. The association between QTc interval and dialysis vintage was studied. Additionally, clinically relevant variables related to QTc duration at 1 year after HD initiation were assessed. Results: Average QTc interval at 4 and 7 years after HD initiation was significantly longer than that at 1 year after HD initiation (443, 445, and 437 ms) (p

Date: 2019
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0209297

DOI: 10.1371/journal.pone.0209297

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