Real-world utilization patterns of systemic immunosuppressants among US adult patients with atopic dermatitis

April W Armstrong, Ahong Huang, Li Wang, Raymond Miao, Miraj Y Patel, Abhijit Gadkari, Usha G Mallya and Jingdong Chao

PLOS ONE, 2019, vol. 14, issue 1, 1-11

Abstract: At the time of this study, prior to the introduction of biologics in the US, systemic therapies used for the treatment of moderate-to-severe atopic dermatitis included off-label immunosuppressants and corticosteroids. Immunosuppressant therapy is associated with a substantial risk of side-effects, therefore needing clinical monitoring, and is likely to incur a significant healthcare burden for patients and payers. This retrospective cohort study based on claims data measured immunosuppressant use and its associated burden among US adult patients with atopic dermatitis covered under commercial or Medicare Supplemental insurance from January 01, 2010, to September 30, 2015. Overall, based on age, gender, region, and index year, 4201 control patients with atopic dermatitis without immunosuppressant use were matched with 4204 patients treated with immunosuppressants. The majority (68.5%) of patients using immunosuppressants were non-persistent with immunosuppressant treatment during the 12-month follow-up period after a mean (standard deviation) of 88.1 (70.7) days of immunosuppressant use; 72.3% required systemic steroid rescue treatment. Immunosuppressant users had higher incidence of immunosuppressant-related clinical events than controls; in addition, a larger proportion of immunosuppressant users versus controls developed cancer (0.28% vs 0.14%, respectively; P

Date: 2019
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0210517

DOI: 10.1371/journal.pone.0210517

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