Symmetry and spatial distribution of muscle glucose uptake in the lower limbs during walking measured using FDG-PET

Sjoerd Kolk, Edzo Klawer, Eric Visser, Daphne Lobeek, Jan Schepers, Nico Verdonschot and Vivian Weerdesteyn

PLOS ONE, 2019, vol. 14, issue 4, 1-19

Abstract: Purpose: This study aimed to elucidate whether muscle activity (in terms of glucose uptake) between the legs can be considered symmetrical during walking. Furthermore, we aimed to determine whether the [18F]-fluorodeoxyglucose was distributed heterogeneously throughout each muscle, and if so, whether areas of high uptake would be clustered. Methods: Ten healthy participants walked on a treadmill at self-selected comfortable walking speed for a total of 90 minutes, 60 minutes before and 30 minutes after intravenous injection of 50 MBq [18F]-fluorodeoxyglucose. Thereafter, a positron emission tomography/computed tomography scan of the lower limb was acquired. Three-dimensional muscle contours of 78 (= 39x2) muscles of the left and right lower limb were semi-automatically determined from magnetic resonance imaging scans. After non-rigid registration, those muscle contours were used to extract [18F]-fluorodeoxyglucose uptake from the positron emission tomography scans. Results: Large asymmetries were observed in the lower leg muscles (e.g. median absolute asymmetry index of 42% in the gastrocnemius medialis) and in the gluteus minimus (30% asymmetry) and gluteus medius (15% asymmetry), whereas the uptake in the thighs was relatively symmetrical between the limbs (

Date: 2019
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0215276

DOI: 10.1371/journal.pone.0215276

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