Early-life dentine manganese concentrations and intrinsic functional brain connectivity in adolescents: A pilot study

Erik de Water, Demetrios M Papazaharias, Claudia Ambrosi, Lorella Mascaro, Emilia Iannilli, Roberto Gasparotti, Roberto G Lucchini, Christine Austin, Manish Arora, Cheuk Y Tang, Donald R Smith, Robert O Wright and Megan K Horton

PLOS ONE, 2019, vol. 14, issue 8, 1-13

Abstract: Maturational processes in the developing brain are disrupted by exposure to environmental toxicants, setting the stage for deviant developmental trajectories. Manganese (Mn) is an essential nutrient that is neurotoxic at high levels of exposure, particularly affecting the basal ganglia and prefrontal cortex. Both the intensity and timing of exposure matter; deciduous teeth can be used to retrospectively and objectively determine early-life windows of vulnerability. The aim of this pilot study was to examine associations between prenatal, early postnatal and childhood dentine Mn concentrations and intrinsic functional connectivity (iFC) of adolescents’ brains. 14 adolescents (12–18 years; 6 girls) from northern Italian regions with either current, historic or no Mn contamination, completed a 10-minute resting state functional Magnetic Resonance Imaging (MRI) scan in an 1.5T MRI scanner. We estimated prenatal, early postnatal and childhood Mn concentrations in deciduous teeth using laser ablation-inductively coupled plasma-mass spectrometry. We performed seed-based correlation analyses, focusing on six subcortical seeds (left and right caudate, putamen, pallidum) and one cortical seed (bilateral middle frontal gyrus) from Harvard-Oxford atlases. We examined linear and quadratic correlations between log-transformed Mn concentrations and seed-based iFC (Bonferroni-corrected p

Date: 2019
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0220790

DOI: 10.1371/journal.pone.0220790

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