Associations between industry involvement and study characteristics at the time of trial registration in biomedical research

Anna Lene Seidler, Kylie E Hunter, Nicholas Chartres and Lisa M Askie

PLOS ONE, 2019, vol. 14, issue 9, 1-12

Abstract: Background: Commercial or industry funding is associated with outcomes that favour the study funder in published studies, across various areas of research. However, it is currently unclear whether there are differences between trials with and without industry involvement at the stage of trial registration. Objective: To determine whether industry involvement (industry sponsorship, funding, or collaboration) is associated with trial characteristics at the time of trial registration. Methods: We conducted a cross-sectional analysis of all interventional studies registered on the Australian New Zealand Clinical Trials Registry in 2017 and classified them by industry involvement. We analysed whether there were differences in study characteristics (including type of control, sample size, study phase, randomisation, registration timing, and purpose of study) by industry involvement. Results: Industry involvement was reported by 21% of the 1,433 included trials. Only 40% of trials with industry involvement used an active control compared to 58% of non-industry trials (OR = 0.49, 95%CI = 0.38 to 0.63, p

Date: 2019
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0222117

DOI: 10.1371/journal.pone.0222117

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