Impact of tear metrics on the reliability of perimetry in patients with dry eye

Hideto Sagara, Tetsuju Sekiryu, Kimihiro Imaizumi, Hiroaki Shintake, Urara Sugiyama and Hiroki Maehara

PLOS ONE, 2019, vol. 14, issue 9, 1-12

Abstract: Background: The application of artificial tears before performing perimetry can improve the reliability and results of perimetry in patients with glaucoma and dry eye (DE). However, the effects of ocular surface and tear film conditions on perimetry measurements and reliability have not been fully characterized. Methods: This prospective, cross-sectional, multicenter study investigated tear metrics in perimetry and assessed the relationships that existed among ocular surface condition, tear condition, and perimetry reliability. Forty-three eyes (43 patients) with DE disease according to the 2016 Japanese diagnostic criteria of DE and 43 eyes (43 subjects) of age- and visual field mean deviation-matched normal control subjects were studied. Perimetry was performed using the Humphrey Field Analyzer (30–2 SITA-Standard). Schirmer’s test, strip meniscometry value, blink rate, tear film break-up time (TFBUT), fluorescein staining of ocular surface, and Dry Eye-related Quality of Life Score (DEQS) were measured. Blink rate was re-measured during perimetry. TFBUT and fluorescein staining were re-evaluated after perimetry. Perimetry reliability was evaluated with fixation loss, false-positive, and false-negative rates. Results: Blink rate during perimetry was significantly lower for both patients with DE and normal controls (both P

Date: 2019
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0222467

DOI: 10.1371/journal.pone.0222467

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