Quality of medicines for life-threatening pregnancy complications in low- and middle-income countries: A systematic review

Maria Regina Torloni, Mercedes Bonet, Ana Pilar Betrán, Carolina C Ribeiro-do-Valle and Mariana Widmer

PLOS ONE, 2020, vol. 15, issue 7, 1-18

Abstract: Background: There are concerns about the quality of medicines available in low- and middle-income countries (LMIC) to manage hemorrhage, pre-eclampsia/eclampsia and sepsis. We aimed to identify, critically appraise, and synthesize the findings of studies on the quality of these three types of medicines available in LMIC. Methods: This systematic review searched Medline, EMBASE and LILACS (from inception to 25 May 2020) for studies on the quality of selected medicines available in LMIC that provided at least the amount of active pharmaceutical ingredient. We contacted study authors for additional information. We excluded simulation studies. We used the MEDQUARG tool to assess study quality. The main outcome was the prevalence of failed samples. Findings: We identified 9699 unique citations and included 34 studies (3159 samples from 40 countries) in the review. Most studies (65%) had low quality (scores

Date: 2020
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0236060

DOI: 10.1371/journal.pone.0236060

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