A systematic review and meta-analysis for association of Helicobacter pylori colonization and celiac disease

Fazel Isapanah Amlashi, Zahra Norouzi, Ahmad Sohrabi, Hesamaddin Shirzad-Aski, Alireza Norouzi, Ali Ashkbari, Naghme Gilani, Seyed Alireza Fatemi and Sima Besharat

PLOS ONE, 2021, vol. 16, issue 3, 1-15

Abstract: Background and objectives: Based on some previous observational studies, there is a theory that suggests a potential relationship between Helicobacter pylori (H. pylori) colonization and celiac disease (CeD); however, the type of this relationship is still controversial. Therefore, we aimed to conduct a systematic review and meta-analysis to explore all related primary studies to find any possible association between CeD and human H. pylori colonization. Data sources: Studies were systematically searched and collected from four databases and different types of gray literature to cover all available evidence. After screening, the quality and risk of bias assessment of the selected articles were evaluated. Synthesis methods: Meta-analysis calculated pooled odds ratio (OR) on the extracted data. Furthermore, heterogeneity, sensitivity, subgroups, and publication bias analyses were assessed. Results: Twenty-six studies were included in this systematic review, with a total of 6001 cases and 135512 control people. The results of meta-analysis on 26 studies showed a significant and negative association between H. pylori colonization and CeD (pooled OR = 0.56; 95% CI = 0.45–0.70; P

Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0241156

DOI: 10.1371/journal.pone.0241156

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