Prognostic and clinicopathological significance of NRF2 expression in non-small cell lung cancer: A meta-analysis

Qingsong Wang, Liang Xu, Gang Wang, Lei Chen, Changping Li, Xiangli Jiang, Hai Gao, Bing Yang and Weiping Tian

PLOS ONE, 2020, vol. 15, issue 11, 1-16

Abstract: Nuclear factor erythroid 2-related factor 2 (NRF2) functions as a transcription factor and regulates a wide array of antioxidant and stress-responsive genes. NRF2 has been widely implicated in different types of cancers, but only limited studies concerning the relationship between NRF2 expression and tumour invasion or prognosis in lung cancer. Therefore, we conducted a meta-analysis to determine the prognostic value of NRF2 in patients with non-small cell lung cancer (NSCLC). The relationship between NRF2 expression in NSCLC patients and clinicopathological features was also investigated. Overall survival (OS) and treatment response rate were evaluated using STATA software. Twenty eligible articles with 2530 lung cancer patients were included in this meta-analysis. The results revealed that high expression level of NRF2 was associated with pathologic distant metastasis (odds ratio (OR) = 2.64, 95% confidence interval (CI) 1.62–4.31; P

Date: 2020
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0241241

DOI: 10.1371/journal.pone.0241241

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