Comparing the Voets equation and the Adrogue-Madias equation for predicting the plasma sodium response to intravenous fluid therapy in SIADH patients

Philip J G M Voets, Nils P J Vogtländer and Karin A H Kaasjager

PLOS ONE, 2021, vol. 16, issue 1, 1-8

Abstract: Background: The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is one of the most common causes of hypotonic hyponatremia. In our previous work, we have derived a novel model (Voets equation) that can be used by clinicians to predict the effect of crystalloid intravenous fluid therapy on the plasma sodium concentration in SIADH. Methods: In this retrospective chart review, the predictive accuracy of the Voets equation and the Adrogue-Madias equation for the plasma sodium response to crystalloid infusate was compared for fifteen plasma sodium response measurements (n = 15) in twelve SIADH patients. The medical records of these patients were accessed anonymously and none of the authors were their treating physicians. The Pearson correlation coefficient r and corresponding p-value were calculated for the predictions by the Voets model compared to the measured plasma sodium response and for the predictions by the Adrogue-Madias model compared to the measured plasma sodium response. Results and conclusion: The presented results show that the Voets model (r = 0.94, p

Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0245499

DOI: 10.1371/journal.pone.0245499

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