A review of methods for addressing components of interventions in meta-analysis

Maria Petropoulou, Orestis Efthimiou, Gerta Rücker, Guido Schwarzer, Toshi A Furukawa, Alessandro Pompoli, Huiberdina L Koek, Cinzia Del Giovane, Nicolas Rodondi and Dimitris Mavridis

PLOS ONE, 2021, vol. 16, issue 2, 1-15

Abstract: Many healthcare interventions are complex, consisting of multiple, possibly interacting, components. Several methodological articles addressing complex interventions in the meta-analytical context have been published. We hereby provide an overview of methods used to evaluate the effects of complex interventions with meta-analytical models. We summarized the methodology, highlighted new developments, and described the benefits, drawbacks, and potential challenges of each identified method. We expect meta-analytical methods focusing on components of several multicomponent interventions to become increasingly popular due to recently developed, easy-to-use, software tools that can be used to conduct the relevant analyses. The different meta-analytical methods are illustrated through two examples comparing psychotherapies for panic disorder.

Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0246631

DOI: 10.1371/journal.pone.0246631

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