High quantities: Evaluating the association between cannabis use and propofol anesthesia during endoscopy

Ngozi Imasogie, Rhiannon V Rose and Aze Wilson

PLOS ONE, 2021, vol. 16, issue 3, 1-6

Abstract: Background: Endoscopy under propofol sedation has become a routine procedure. Given the number of Canadians undergoing an endoscopy annually, as well as the pervasive use of cannabis by many patients, understanding the effect of cannabis use on the propofol dose at endoscopy is highly relevant. We aimed to evaluate the association between cannabis exposure and the propofol dose needed to achieve adequate sedation at endoscopy. Methods: A case-control study of individuals undergoing endoscopy was conducted at a single outpatient endoscopy clinic in London, Ontario between 2014 and 2017. Cases included all individuals with any self-reported cannabis exposure, while controls included all individuals without any self-reported history of cannabis use. Dose of propofol administered by a single anesthetist was collected on each subject as well as additional demographic and procedure-related covariates. Results: Three hundred and eighteen participants were included (cases, n = 151; controls, n = 167). Cannabis exposure was associated with an increase in propofol dose (cases 0.33 mg/kg/minute ±0.24; controls, 0.18 mg/kg/minute ±0.11; p

Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0248062

DOI: 10.1371/journal.pone.0248062

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