Association of perioperative serum carcinoembryonic antigen level and recurrence in low-risk stage IIA colon cancer

Han-Gil Kim, Seung Yoon Yang, Yoon Dae Han, Min Soo Cho, Byung Soh Min, Kang Young Lee, Nam Kyu Kim and Hyuk Hur

PLOS ONE, 2021, vol. 16, issue 6, 1-11

Abstract: Background: The purpose is to investigate prognosis according to serum CEA levels before and after surgery in patients with stage IIA colon cancer who do not show high-risk features. Methods: Among the patients diagnosed with colon adenocarcinoma between April 2011 and December 2017, 462 patients were confirmed as low-risk stage IIA after surgery and enrolled. The ROC curve was used to determine cut-off values of pre- and postoperative CEA. Patients were classified into three groups using these new cut-off values. Results: All recurrence occurred in 52 of 463 patients (11.2%). However, recurrence in group H was 15.9%, which was slightly higher than the other two groups (P = 0.04). Group L and M showed 10.5% and 12.8% overall survival, group H was higher at 21.0% (P = 0.005). Recurrence was the only risk factor in group H was significantly higher in group L (HR 2.008, 95% CI, 1.123–3.589, P = 0.019). Mortality was similar to recurrence (HR 1.975, 95% CI 1.091–3.523, P = 0.044). Conclusion: Among patients with low-risk stage IIA colon cancer, recurrence and mortality rates were higher when perioperative serum CEA levels were above a certain level. Therefore, high CEA level should be considered a high-risk feature and adjuvant chemotherapy should be performed.

Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0252566

DOI: 10.1371/journal.pone.0252566

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