On-admission SARS-CoV-2 RNAemia as a single potent predictive marker of critical condition development and mortality in COVID-19

Shoji Miki, Hiroaki Sasaki, Hiroshi Horiuchi, Nobuyuki Miyata, Yukihiro Yoshimura, Kazuhito Miyazaki, Takayuki Matsumura, Yoshimasa Takahashi, Tadaki Suzuki, Tetsuro Matano, Ai Kawana-Tachikawa and Natsuo Tachikawa

PLOS ONE, 2021, vol. 16, issue 7, 1-11

Abstract: Background: This study aimed to clarify how SARS-CoV-2 RNAemia is related to COVID-19 critical condition development and mortality in comparison with other predictive markers and scoring systems. Methods: This is a retrospective cohort study conducted at Yokohama Municipal Citizen’s Hospital and National Institute of Infectious Diseases. We recruited adult patients with COVID-19 admitted between March 2020 and January 2021. We compared RNAemia with clinical status on admission including scoring systems such as the 4C Mortality, CURB-65, and A-DROP, as well as the Ct value of the nasopharyngeal PCR, in predicting COVID-19 mortality and critical condition development. Results: Of the 92 recruited patients (median age, 58; interquartile range, 45–71 years), 14 (14.9%) had RNAemia. These patients had an older age (median, 68 years vs. 55.5 years; p = 0.011), higher values of lactated dehydrogenase (median, 381 U/L vs. 256.5 U/L, p

Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0254640

DOI: 10.1371/journal.pone.0254640

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