Effects of blood urea nitrogen independent of the estimated glomerular filtration rate on the development of anemia in non-dialysis chronic kidney disease: The results of the KNOW-CKD study

Hyo Jin Kim, Tae Eun Kim, Miyeun Han, Yongin Yi, Jong Cheol Jeong, Ho Jun Chin, Sang Heon Song, Joongyub Lee, Kyu-Beck Lee, Suah Sung, Seung Hyeok Han, Eun Young Seong, Curie Ahn, Kook-Hwan Oh and Dong-Wan Chae

PLOS ONE, 2021, vol. 16, issue 9, 1-21

Abstract: Background: Anemia is a common complication of chronic kidney disease (CKD). Blood urea nitrogen (BUN) in CKD represents nitrogenous uremic toxin accumulation which could be involved in anemia of CKD. We investigated the effects of BUN independent of estimated glomerular filtration rate (eGFR) on anemia in non-dialysis CKD (NDCKD). Methods: This prospective study included 2,196 subjects enrolled in the KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease (KNOW-CKD) cohort with BUN and hemoglobin level data. Initially, we investigated the association between BUN and hemoglobin level. To examine the impact of baseline BUN on the incident anemia, a longitudinal study was performed on 1,169 patients without anemia at study enrollment. BUN residuals were obtained from the fitted curve between BUN and eGFR. Anemia was defined as a hemoglobin level of

Date: 2021
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Persistent link: https://EconPapers.repec.org/RePEc:plo:pone00:0257305

DOI: 10.1371/journal.pone.0257305

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